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nerve growth factor (ngf) antibodies with enhanced in vivo stability
nerve growth factor (ngf) antibodies with enhanced in vivo stability
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机译:神经生长因子(ngf)抗体具有增强的体内稳定性
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摘要
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
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