T cell immunosuppressive antibody, immunoglobulin domain and immunosuppressive thyroid based suppressor (titit)

摘要

Current inventions provide antibodies or fragments that bind to antigens that bind to human tigit, a T-cell immunosuppressant with Ig and ITIM domains,The same antibodies or fragments are used for therapeutic purposes, such as cancer or chronic viral infection. This treatment includes inhibition therapy combined with other interactions of the immune receptor, such as PD-1 / PD-L1 interaction. The invention also provides polynucleotide to encode the variable region of antibody light and / or heavy chain, the expression vector includes polynucleotide to encode the variable region of antibody light and / or heavy chain,Cells include vectors and methods for the production of antibodies or cell fragments.