Preparation of modified release of Naproxen Sodium

摘要

The present Invention is a formulation that Naproxen has a release profile that provides immediate Relief of Pain equivalent to 440 mg (2 Tablets of Naproxen S 220 mg)u00f3dico and also extended Pain Relief during 24 hours.In particular,The present Invention is an individual who combines a Solid dose proportion only a product of immediate release of Naproxen Sodium with a layer of extended release of Naproxen su00f3diCo.More particularly,The present Invention is a two-layer tablet. It immediately releases 300 to 320 mg of Naproxen Sodium and then gradually releases 450 480 mg Naproxen Sodium.This product is able to provide 24 hours of Pain Relief when given as one Tablet two individual layers.The two individual compressed layers provides Immediate Release (IR) of Naproxen Sodium for pain relief of the initial Layer followed by Continuous release of Naproxen Sodium rEmanente of another Layer to maintain the spread of Pain Relief for up to 24 hours.