Sustained Release of Naproxen Sodium from Electrospun Aligned PLLA/PCL Scaffold for Tendon Tissue Regeneration

摘要

In this work, NPS was loaded into electrospun PLLA/PCL scaffolds with aligned, headless and continuous fibrous morphology. By adjusting the H_2O content, a two-week sustained release could be achieved. In vitro cell studies showed that L929 cells could proliferate and align to the fiber orientation. These optimized PLLA/PCL scaffolds possess both sustained NPS releasing ability and desirable tendon TE characteristics, and could have good potential in achieving better tendon regeneration.