A method of producing 5-amino-4-(1-cyclopropylnaphthalen-4-yl)-4H-1,2,4-triazole-3-thiol, a key intermediate for the production of 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4H-1,2,4-triazol-3ylthio)acetic acid - lesinurade

摘要

the solution relates to the improved production method of highly pure intermediu00e1tu 5 - amino - 4 - (1 - cyklopropylnaftalen - 4 - yl) - 4h - 1,2,4-triazole - 3 - thiol moiety to form the formula.a key intermediate in the production of 2 - (5 - bromine - 4 - (1 - cyclopropyl - naphthalene - 4 - yl) - 4h - 1,2,4-triazole - 3 - ylthio) acetic acid formula ii, known under the generic name lesinurad.highly pure intermediu00e1t prepare response 4 - cyclopropyl - 1 - naftylisothiokyanu00e1tu with appropriate with - alkylthiosemikarbazidem in a suitable solvent.lesinurad is a selective inhibitor of the transport of uric acid lowering uric acid level in the blood.it is used in combination with any of the drugs acting as inhibitors of xanthin oxidase patients reach the satisfactory condition treatment using the xanthin oxidase inhibitors.