New crystalline forms of 2-((5-bromo-4-(4cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid

摘要

Here we describe new crystalline forms of 2-((5-bromo-4-(4cyclopropylnaphthalen-1-yl)-4H-1,2.4-triazol-3-yl)thio)acelic acid, which have been prepared starting from 2-((5-bromo-4-(4cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acctic acid in its crystalline form 2 disclosed in patent document WO 2012092395. Preparation of a crystalline methanol solvate of 2-((5-brorno-4-(4cyelopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)(hio)acelic acid: The compound 2-((5-bromo-4-(4cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid (30 mg) in its crystalline form 2 was dissolved in the minimum amount of methanol at 50 ℃. Once completely dissolved, the obtained solution was quickly cooled to 0 ℃ using an ice bath. A crystalline methanol solvate of 2-((5-bromo-4-(4cyc lopropylnaphthalen-1-yl)-4H-1,2.4-triazol-3-yl)thio(acetic acid was thus obtained. Said methanol solvate was characterised by powder X-ray diffraction(PXRD) using a CuK radiation, differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA).