TRANSGENE MOUSE EXPRESSING HUMAN LAMBDA AND CAPTAIN IMMUNOGLOBULIN EASY VARIABLE DOMAINS

摘要

The invention discloses methods for the generation of chimaeric human - non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.