1- 7- (cis-4-methyl-cyclohexyloxy) -8-trifluoromethyl-naphthalen-2-ylmethyl -piperidine-4-carboxylic acid derivatives as autotaxin (ATX) modulators for the treatment of inflammation and autoimmune disorders

摘要

Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.