OPTIMIZED COMBINED THERAPY AND ITS APPLICATION FOR THE TREATMENT OF MALIGNANT TUMOR AND AUTOIMMUNE DISEASE

摘要

A series of new multi-substituted fluorine pyrazolopyrimidine compounds or salts are presented. The compounds are Bruton tyrosine kinase inhibitors (BTKs). The compounds have better kinase inhibition selectivity and pharmacokinetic properties. A method for producing compounds is also provided. Combination therapy is also presented, which includes compounds in combination with a composition of another targeted drug or with another drug. The optimized combination therapy has a cooperative effect, suppressing an existing tumor better than a unidirectional drug, and causing the complete disappearance of certain tumors. The optimized combination therapy cures the resistance of the tumor to the drug and the recurrence of the malignant tumor is better than the unidirectional drug, and the treatment cycle is shorter. The present invention also relates to a combination compound and a pharmaceutical formulation, wherein said combination compound acts as an active ingredient, wherein said pharmaceutical formulation is safer in lower doses and has a cooperative effect efficacy. A method of using compounds and their preparation for the treatment and suppression of an autoimmune disease or disorder, a heterogeneous autoimmune disease or disorder, an inflammatory disease, a malignant tumor or a disorder is also provided.