HETEROMULTIMERA RECEPTORS TYPE I AND TYPE II PROTEINS OF THE TGF-BETA SUPERFAMILY

摘要

In some aspects, the invention provides soluble heteromeric polypeptide complexes comprising the extracellular domain of the type I serine / threonine kinase receptor proteins of the TGF-beta family and the extracellular domain of the type II serine / threonine kinase receptor proteins of the TGF-beta family. In some embodiments, the invention provides soluble polypeptide complexes comprising the extracellular domain of a type II receptor selected from ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the invention provides soluble polypeptide complexes comprising the extracellular domain of a type I receptor selected from ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally, the soluble complex is a heterodimer. In some aspects, such soluble polypeptide complexes can be used to regulate (stimulate or inhibit) the growth of tissues or cells, including, for example, muscle, bone, cartilage, adipose tissue, nerve tissue, tumors, malignant cells and / or hematopoietic germ cells, including red blood cells . In some aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cell networks, and endocrine systems.