TGF-BETA SUPERFAMILY TYPE II RECEPTOR HAVING BINDING AFFINITY FOR BONE MORPHOGENIC PROTEIN (BMP)

摘要

The present invention relates to a novel TGF-β superfamily type II receptor having binding affinity for a bone morphogenic protein, osteogenic protein 1 (OP-1). The novel type II receptor has a serine/threonine kinase domain followed by a long serine and threonine rich region in the C-terminal end. The invention further provides nucleic acids encoding the novel type II receptor as well as vectors and host cells expressing the nucleic acids and recombinant production methods using the nucleic acids. Complexes of the novel type II receptor with an appropriate TGF-β superfamily type I receptor are also provided.