COMPOSITIONS ON THE BASIS OF IRNA FOR FACTOR XII (HAGEMAN FACTOR) (F12), PLASMA KALLIKREIN B (FLETCH FACTOR) 1 (KLKB1) AND KININOGEN 1 (KNG1) AND FOSTER OF THE FLETCHER) (1)

摘要

The present invention relates to agents for RNAi, for example, double-stranded agents for RNAi specifically targeting the plasma kallikrein B gene (Fletcher factor) 1 (KLKB1), the factor XII gene (Hagemann factor (F12) or the kininogen 1 gene (KNG1), and methods of using such agents for RNAi to inhibit the expression of the KLKB1 gene, the F12 gene and / or the KNG1 gene, and to methods of treating subjects with hereditary angioedema (HAE) and / or a disorder associated with contact by activating blood coagulation.