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METHOD OF CONJUGATING A WATER SOLUBLE POLYMER TO A THERAPEUTIC PROTEIN (EMBODIMENTS) AND OBTAINED MODIFIED PROTEIN
METHOD OF CONJUGATING A WATER SOLUBLE POLYMER TO A THERAPEUTIC PROTEIN (EMBODIMENTS) AND OBTAINED MODIFIED PROTEIN
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机译:将水溶性聚合物与治疗性蛋白质(实施方案)和获得的改性蛋白质缀合的方法
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摘要
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
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