METHODS OF TREATING PATIENTS WITH MALIGNANT TUMORS WITH THE USE OF PHARNESILTRANSFERASE INHIBITORS

摘要

The present invention relates to the field of molecular biology and biology of malignant tumors. Specifically, the present invention relates to methods for treating a subject using a farnesyltransferase inhibitor (FTI), which include determining whether a subject is likely to respond to FTI treatment based on genotyping and obtaining expression profiles of specific immunological genes and the status of RAS mutations in a subject.