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Dll4 antagonists and vegf inhibitor for use in methods for inhibiting tumor development or growth
Dll4 antagonists and vegf inhibitor for use in methods for inhibiting tumor development or growth
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机译:Dll4拮抗剂和vegf抑制剂,用于抑制肿瘤发展或生长的方法
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摘要
A therapeutic method for inhibiting tumor development or growth, comprising administering an agent capable of inhibiting human delta-like ligand 4 (DII4) activity to a subject in need thereof. In one embodiment, the agent is an anti-DII4 antibody or antibody fragment capable of inhibiting the binding of DII4 to a Notch receptor. In another embodiment, the agent is a fusion protein comprising the extracellular domain of DII4 or a fragment or variant thereof, fused to a multimerizing component such as an Fc domain. The method of the invention is useful for inhibiting tumor growth, particularly in tumors which are not responsive to other therapeutic agents.
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