OLIGO-GUANIDINES BASED CELLULAR TRANSPORTER COMPRISING HETEROCYCLIC RINGS WITH HYDROPHOBIC AND/OR LIPOPHILIC GROUPS AT N-TERMINAL FOR EFFECTIVE DELIVERY OF NONPENETRABLE CARGOS IN-VITRO AND IN-VIVO

摘要

Oligo-guanidines based cellular transporter are provided comprising heterocyclic rings including 4-aminopiperidine, piperazine, morpholine having at least one N-terminal based heterocyclic ring or at least one O-heteroatom based heterocyclic ring tailored with hydrophobic and/or lipophilic group and related compounds adapted as cell penetrating agents/ carriers, and also relates to its method of preparation. Said oligo-guanidines are adapted as effective molecular transporters for transport and/or delivery of therapeutics, therapeutic candidates, probes, or other molecules of interest across biological barriers including oligonucleotides. Advantageously, said oligo-guanidines are capable of being internalized into cells (in-vitro and in-vivo) with enhanced cellular uptake in nanomolar concentration.