IN VITRO ENGINEERED VIRUS-LIKE PARTICLES FROM FLOCK HOUSE VIRUS CAPSID PROTEINS AND USES THEREOF

摘要

The present invention relates to viral nanoparticle capsid protein sequence obtained from capsid protein of Flock House Virus. The said sequence is engineered in vitro by addition of a hexahistidine (6x-his) tag to the N-terminal end of the capsid protein alpha and includes a peptide sequence in the region between amino acid residue 207 and amino acid residue 208. Present invention also relates to method of processing the said viral nanoparticle capsid protein sequence in vitro and the process of cellular deliveryof macromolecules using said viral nanoparticle to a target cell. Fig: 1