STABLE FORMULATION DEVELOPMENT FOR NITROGLYCERIN SUBLINGUAL TABLETS BY DIRECT COMPRESSION TECHNIQUE WITH POVIDONE AND CROSPOVIDONE

摘要

A stable sublingual composition with fast disintegration time of less than 25 seconds is provided. The composition which is formulated into stable sublingual tablets by direct compression technique includes (a) 15% by wt. of 10% nitroglycerin in lactose; (b) 76.0-78.3% by wt. of lactose monohydrate; (c) 1.5-2.5% by wt. of povidone; (d) 3.0-4.0% by wt. of crospovidone; (e) 1.5-2.5% by wt. of colloidal silicon dioxide; and (f) 0.5-1.0% by wt. of magnesium stearate.