3-INDOLYL FURANOIDS AS INHIBITORS OF MATRIX METALLOPROTEINASE-9 FOR PREVENTION OF GASTRIC ULCER AND OTHER INFLAMMATORY DISEASES

摘要

The present invention relates 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. The present invention relates to a compound of formula 1, wherein R1 to R6 is selected from H, OH ,CH3, OCH3, Br , Cl, Ph or o-OHC6H4, OCH2-CH=CH2, or OCH2CH2CH3 and R1 to R6 is having atleast one substituent other than H. The present invention relates to representative compounds of Formula 1 and method of preparation thereof. Further the present invention relates to the use of representative compounds of Formula 1 in treating diseases associated with gastric ulcer and other inflammatory diseases. The promising feature of this invention is the IC50 value of 50 µM of one of the 3-indolyl furanoids.