METHODS FOR DEVELOPMENT AND USE OF MINIMALLY POLARIZED FUNCTION CELL MICRO AGGREGATE UNITS IN TISSUE APPLICATIONS USING LGR4 LGR5 AND LGR6 EXPRESSING EPITHELIAL STEM CELLS

摘要

Provided herein are constructs of micro aggregate multicellular minimally polarized grafts containing Leucine rich repeat containing G protein coupled Receptor (LGR) expressing cells for wound therapy applications tissue engineering cell therapy applications regenerative medicine applications medical/therapeutic applications tissue healing applications immune therapy applications and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.