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ANTI GARP ANTIBODY

机译:你努力变坏

摘要

The present invention relates to an antibody that binds to GARP and is useful as a therapeutic agent against tumors and a method for treating a tumor using the antibody. The present invention addresses the problem of providing an antibody which can be used as a medicine that inhibits the function of Treg in a tumor and thus exhibits a therapeutic effect and a method for treating a tumor using the antibody. An anti GARP antibody that binds to GARP and exhibits a Treg function inhibiting activity and an ADCC activity is obtained. Moreover a medicinal composition for treating tumors said composition containing the antibody is obtained.
机译:本发明涉及一种结合GARP并可用作抗肿瘤治疗剂的抗体,以及使用该抗体治疗肿瘤的方法。本发明解决了提供可以用作抑制肿瘤中Treg功能并因此显示出治疗效果的药物的抗体的问题以及使用该抗体治疗肿瘤的方法。获得了与GARP结合并表现出Treg功能抑制活性和ADCC活性的抗GARP抗体。此外,获得了用于治疗肿瘤的药物组合物,所述组合物包含抗体。

著录项

  • 公开/公告号IN201817011321A

    专利类型

  • 公开/公告日2018-07-13

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN201817011321

  • 申请日2018-03-27

  • 分类号C12N15/02;A61K39/395;A61P35/00;

  • 国家 IN

  • 入库时间 2022-08-21 12:51:52

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