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IGG SUBTYPING ASSAY FOR IDENTIFYING TRANSPLANTABLE TISSUE SAMPLES
IGG SUBTYPING ASSAY FOR IDENTIFYING TRANSPLANTABLE TISSUE SAMPLES
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机译:用于识别可移植组织样品的IGG分型检测
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摘要
The disclosure relates to methods for assessing the suitability of a tissue obtained from a vertebrate (e.g. human) donor for grafting to a recipient such as another vertebrate of the same species. The method involves contacting leukocytes obtained from the donor with serum from the recipient. Binding between recipient antibodies and the leukocytes is assessed specifically focusing on the subtype(s) of IgG antibodies which bind with donor leukocytes. Detected binding between recipient antibodies of subtypes IgG1 and IgG3 indicates that the donor tissue is not suitable for grafting to the recipient. Detected binding between recipient antibodies of subtypes IgG2 and/or IgG4 indicates that the donor tissue can suitably be grafted to the recipient.
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