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A PROCESS FOR THE PREPARATION OF DRONEDARONE HYDROCHLORIDE
A PROCESS FOR THE PREPARATION OF DRONEDARONE HYDROCHLORIDE
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机译:盐酸决奈达隆的制备方法
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摘要
A process for the preparation of dronedarone hydrochloride by using specific ratio of the non-specific P205-methanesulfonic acid reagent for acyiation reaction is disclosed. Dronedarone hydrochloride of formula (3) is prepared by acylating of 2n-butyl-5-sulfonamide benzofuran derivative of formula (1) with benzoic acid derivative of formula (2) by using specific ratio of phosphorous pentoxide to methanesulfonic acid solution. [IN-MUM-2010-00611A]
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