USE OF A MIXTURE OF MODIFIED GLUCOSE POLYMERS FOR REDUCING TUMOR METASTASIS.

摘要

The present invention relates to a solution, in particular a pharmaceutically acceptable solution, comprising icodextrin and hydroxyalkyl starch (HAS), wherein the icodextrin is present at a concentration of from 1 to 7.5 % (w/v) and wherein said HAS is present at a concentration of from 1 to 15 % (w/v). The present invention further relates to the aforesaid pharmaceutically acceptable solution for use as a medicament and for use in (e.g., in methods of) preventing metastasis formation and/or relapse by administration to a body cavity of a subject afflicted with cancer. The present invention further relates to a kit comprising icodextrin and HAS in pre- weighed amounts and a pharmaceutically acceptable means of dissolving the same, to a device comprising a pharmaceutically acceptable solution of the present invention and means for administering the same, as well as to a pharmaceutically acceptable solution comprising icodextrin and hydroxyalkyl starch at a total concentration in the range of from 1 to 20 % (w/v), wherein the weight ratio of the icodextrin relative to the hydroxyalkyl starch is in the range of from 0.05:1 to 5:1, for use in preventing metastasis formation and/or relapse by administration to a body cavity of a subject afflicted with cancer.