DELTA133P53BETA AND DELTA133P53GAMMA ISOFORMS ARE BIOMARKERS OF CANCER STEM CELLS.

摘要

The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p�536 isoform, ?133p�53ß isoform, or both ?133p�536 and ?133p�53ß isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p�536 isoform, ?133p�53ß isoform, or both ?133p�536 and ?133p�53ß isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p536 isoform, ?133p�53ß isoform, or both ?133p�536 and ?133p�53ß isoforms expression; and also to screening methods for anti-cancer stem cells agents.