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RATIONAL COMBINATION THERAPY FOR THE TREATMENT OF CANCER.
RATIONAL COMBINATION THERAPY FOR THE TREATMENT OF CANCER.
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机译:合理的联合疗法治疗癌症。
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摘要
The disclosure provides methods of using inhibitors of chaperone proteins, such as HSP90 inhibitors, in combination with agents that increase proteotoxic stress on tumor cells or agents that induce a biochemical rewiring of the chaperome. The proteotoxic agents are administered prior to administration of the chaperone proteins to achieve synergistic activity.
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