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CHIMERIC NON-INTEGRATING LENTIVIRAL GENOMES AS VACCINES AGAINST HIV-1.
CHIMERIC NON-INTEGRATING LENTIVIRAL GENOMES AS VACCINES AGAINST HIV-1.
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机译:嵌合非整合型宫颈病毒基因组疫苗,用于抵抗HIV-1。
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摘要
The present invention relates to nucleic acids containing chimeric non-integrating retrovirus genomes including the long terminal repeat (LTR) sequences 5' and 3' of the caprine lentivirus, the caprine arthritis/encephalitis virus (CAEV), or another retrovirus that does not integrate into human cells, and at least one viral gene of another retrovirus. The invention also relates to a vector containing such a nucleic acid, to an immunogenic or vaccine composition containing said vector or said nucleic acid, and to the use thereof for treating and/or preventing an infection by a retrovirus or disease induced by a pathogen.
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