Triciclicas sulfone as modulators of retinoid related Orphan receptor gamma (rorgamma)

摘要

Refers to a compound of formula I, wherein X is - - - cr4r5 (CR4, - 2, - ocr6r7 - R5).- S (o) pcr6r7 - or - nr6cr6r7; v e and aromatic rings are independently or heteroaromaticos 5 or 6 Elements; r1 is H, Halo, ocf3, CN, among others; R2 is H, alkyl substituted, NS,Among others, R4 and R5 are independently Hydrogen, alkyl, Halo, C1 - 6, among others; R6 and R7 are independently Hydrogen (C (= o) c1-4 alkyl,Among other; M is 0 to 3; n is 0 - 2, P and q are 0 - 2; t is 0 OR 1. This Compound has tautomeros these stereoisomers, pharmaceutically acceptable salts, solvates or.These compounds are retinoid related Orphan receptor modulators (rorgamma) in a cell, are useful to Diagnose,Prevent or treat a subject who has a disease or a disorder in which the beneficiary of the therapeutically modulating the activity of rorgamma,Such is the case and / or inflammatory autoimmune disorders like rheumatoid arthritis, psoriasis, multiple sclerosis, among others.