Antibodies against human csf-1r for use in induction of lymphocytosis in lymphomas or leukemias

摘要

Referring to an Antibody that binds csf-1r for use in Inducing leukemic Cell lymphocytosis in lymphomas or leukemias.Where the lymphocytosis, increases the percentage of circulating leukemic cells expressing CD19, CD20 and / or in the Peripheral Blood.Where the said Antibody comprises: (a) a variable domain of heavy chain of SEQ ID no: 23 VH and VL light chain variable domain of SEQ ID no: 24Or (b) a variable domain of heavy chain of SEQ ID no: 31 VH and VL light chain variable domain of SEQ ID no: 32(c) a variable domain of heavy chain of SEQ ID no: 39 VH and VL light chain variable domain of SEQ ID no: 40Or (d) a variable domain of heavy chain of SEQ ID no: 47 VH and VL light chain variable domain of SEQ ID no: 48E) or a variable domain of heavy chain of SEQ ID no: 55 VH and VL light chain variable domain of SEQ ID no: 56.It also relates to a combination Therapy of Antibodies that bind to Human csf-1r with Antibodies that bind to human CD20.