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New peptides and New combinations of peptides for use in Immunotherapy and methods to create holders for use against Pancreatic Cancer and other cancers

机译:用于免疫疗法的新肽和肽的新组合,以及创建用于预防胰腺癌和其他癌症的支架的方法

摘要

Referred to a Peptide comprising an Amino Acid Sequence selected from the group consisting of SEQ ID no. 1 to the SEQ ID no.161, sequences and variants thereof that are at least a 88% homologous to the SEQ ID no. 1 to the SEQ ID no.161; in this variant binds to one or more Molecules of the major histocompatibility complex (MHC) and / or induces t-cell Cross reaction with the Peptide Variant.It also relates to a Nucleic Acid encoding a Peptide or a Variant thereof, optionally linked to a heterologous Promoter sequence, AN EXPRESSION vector,A recombinant host cell and Method for producing the Peptide or a Variant thereof.These epitopes Peptide for tumor Associated T cells alone or in combination with other tumor Associated Peptides, e.g.Can serve as active pharmaceutical ingredients in vaccine compositions intended to stimulate antitumor immune responses.To stimulate or ex vivo T lymphocytes which are then transferred to the patients.
机译:指包含选自SEQ ID No.1的氨基酸序列的肽。 SEQ ID No.1至SEQ ID No.161的序列和变体与SEQ ID No.1至少88%同源。 1至SEQ ID No.161;在该变体中的Aβ与主要组织相容性复合物(MHC)的一个或多个分子结合和/或诱导与肽变体的t细胞交叉反应。它还涉及编码肽或其变体的核酸,其任选地与异源启动子序列,表达载体,重组宿主细胞和产生该肽或其变体的方法。这些表位肽可单独或与其他肿瘤相关肽结合用于肿瘤相关T细胞,例如,可作为活性药物成分用于旨在刺激抗肿瘤免疫反应的疫苗组合物。刺激或离体的T淋巴细胞,然后转移给患者。

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