New peptides and New combinations of peptides for use in Immunotherapy and methods to create holders for use against Pancreatic Cancer and other cancers

摘要

Referred to a Peptide comprising an Amino Acid Sequence selected from the group consisting of SEQ ID no. 1 to the SEQ ID no.161, sequences and variants thereof that are at least a 88% homologous to the SEQ ID no. 1 to the SEQ ID no.161; in this variant binds to one or more Molecules of the major histocompatibility complex (MHC) and / or induces t-cell Cross reaction with the Peptide Variant.It also relates to a Nucleic Acid encoding a Peptide or a Variant thereof, optionally linked to a heterologous Promoter sequence, AN EXPRESSION vector,A recombinant host cell and Method for producing the Peptide or a Variant thereof.These epitopes Peptide for tumor Associated T cells alone or in combination with other tumor Associated Peptides, e.g.Can serve as active pharmaceutical ingredients in vaccine compositions intended to stimulate antitumor immune responses.To stimulate or ex vivo T lymphocytes which are then transferred to the patients.