Avian adenovirus vector System (fadv 9 - 9) and associated Methods

摘要

Referring to viral vectors obtained from Avian adenovirus recombinant (fadv 9 - 9), which comprises at least a deletion of a non Essential region of ORF19 selected and orf17.In addition, May include one or more cuts in non Essential regions of the Genome of fadv - 9, as orf0, ORF1, ORF2, TR2 and orf11, on the extreme left and / or right Winger.Also,Includes one or more exogenous nucleotide sequences encoding one or more polypeptides of interest; and it is a double vector comprising two exogenous nucleotide sequences encoding two polIpeptidos of interest. It also relates to methods for producing the viral vector; and its use to generate an immunogenic response in a subject and / or to prevent disease.