Fosfinanos and azafosfinanos New Derivatives, Preparation method thereof and Pharmaceutical compositions containing them

摘要

Relates to compounds of formula (i) wherein AK1 represents a c1-c6 alkyl Chain, X represents - (CH2) - M, - ch (R) - N - (R) -, among others, and M is a number from 1 to 4.R represents a hydrogen Atom or an alkyl group, among others. R1 and R2 represent each a hydrogen Atom, among others. R3 represents AK3 - NH - NH, Cy or piperidin-4-yl ILO, among others.R4 and R5 is Hydrogen Atom or Fluorine.These compounds are used in the treatment and Prevention of thrombotic Events, cardiovascular, pulmonary, cerebrovascular disease, hyperlipidemia, diabetes, Alzheimer's disease,Among others.Among the compounds we have preferred the following: Acid 2 - (3-aminopropyl) - 1 - hydroxy - 2 - 1 - 2 - oxo carboxylic fosfolano -,Trifluoroacetate acid; 2 - (4 - aminobutil) - 1 - hydroxy - 2 - 1 - 2 - oxo - fosfolano trifluoroacetate; carboxylic acid, among others.