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Phosphonates of acetylene derivatives of betulin with antitumour effects, method for producing them and applications
Phosphonates of acetylene derivatives of betulin with antitumour effects, method for producing them and applications
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机译:具有抗肿瘤作用的白桦蛋白乙炔衍生物的膦酸酯,其制备方法和应用
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摘要
the application describes acetylenowych phosphonates derivatives of betulin having an anticancer action, model 2, in which carbon atoms c29 or c30 group izopropenylowej associated group (the rest) fosfonowa, dashed lines between c20 and c30 c29 and indicate that the binding between them can be double or single, and different substituents r means hydrogen atom, means:the group alkilowu0105 (c1 - c4), allilowu0105, r1 is hydrogen atom, a group alkilowu0105 (c1 - c1), allilowu0105, r2 is a hydroxyl group, oxo group, alkanoiloksylowu0105, alkenoiloksylowu0105, propynoiloksylowu0105, cyklopropylopropynoiloksylowu0105, 2 - butynoiloksylowu0105, 3 - butynoiloksylowu0105, fenylopropynoiloksylow s, 3 - karboksypropynoiloksylowu0105, propyloksykarbonyloksylowu0105, propenoksykarbonyloksylowu0105,propargiloksykarbonyloksylowu0105, 2 - butynyloksykarbonyloksylowu0105, 3 - butynyloksykarbonyloksylowu0105, propargiloksylowu0105, 2 - butynyloksylowu0105, 3 - butynyloksylowu0105 and group alkinyloksylowu0105 (c1 - c10) containing one or more amide triple, triple and double binding in the enodi ynowym or enoynowym, also hydroksylowy terminal substituent, an amino chloridic, bromkowy,r3 means a group hydroksymetylowu0105, karboksylowu0105, aldehyde, alkanoiloksymetylowu0105, alkenoiloksymetylowu0105, propynoiloksylometylowu0105, cyklopropylopropynoiloksymetylowu0105, 2 - butynoiloksymetylowu0105, 3 - butynoiloksymetylowu0105, fenylopropynoiloksylometylowu0105, 3 - karboksypropynoiloksylometylowu0105, propylok sykarbonyloksymetylowu0105, 2 - propenoksykarbonyloksylometylowu0105, propargiloksykarbonyloksymetylowu0105,2 - butynyloksykarbonyloksymetylowu0105, 3 - butynyloksykarbonyloksymetylowu0105, propargiloksymetylowu0105, 2 - butynyloksymetylowu0105, 3 - butynyloksymetylowu0105 and group alkinyloksymetylowe (c1 - c10) containing one or more amide triple, triple and double binding in the enodiynowym or enoynowym, also hydroksylowy terminal substituent, an amino chloridic, bromkowy.the object of the application is also their manufacture and use.
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