new derivatives of 3,4 - dihydroizochinolino - 3 - carboxylic anticancer properties, their synthesis, pharmaceutical compositions containing these derivatives, and their use

摘要

The object of the invention is 3,4-dihydroisoquinoline derivative of structure represented by formula I, wherein R1is selected from the group consisting of H, COOEt, COOH, COOBn; R2 is selected from the group consisting of H, COOEt, COOH, COOBn; R3is selected from the group consisting of OH, OBn; R4is selected from the group consisting of OH, H, OBn; Rsis selected from the group consisting of OH, OBn; and isomers, salts, hydrates and solvates thereof, as well as the method of preparation thereof; pharmaceutical composition comprising the above mentioned derivative and use thereof.