Crystalline form of the complex of dihydrate ((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)chloro(1,10-phenanthroline) copper(II) and method for producing it

摘要

the application relates to crystalline forms of dihydrate ((2s) - 2 - amino - 3 - (4-hydroxy-3,5-diiodophenyl) - propane) chloro (1,10 - fenantrolina) copper (ii) of formula 1.method of manufacturing crystalline forms also revealed complex dihydrate ((2s) - 2 - amino - 3 - (4-hydroxy-3,5-diiodophenyl) - propane) chloro (1,10 - fenantrolina) copper (ii) with formula 1, which is characterized by the fact that one hi molar hydrated salt selected from copper (ii) about wzo the general 2u2022nh2o cu (x), in which x represents cl -.ch3coo - and n is a number from 1 to 2 or salt sulphate (vi) copper (ii) is dissolved in water and subjected to the reaction with two parts molowymi aqueous solution acid dihydrate (2s) - 2 - amino - 3 - (4-hydroxy-3,5-diiodophenyl) - propanowego with added a few drops of concentrated acid the general formula hx, in which x represents cl -.ch3coo - or sulphuric acid (vi) and one part of metanolowego molar solution hydratu 1,10 fenantroliny and minimum one week is a crystalline form of the compound dihydrate ((2s) - 2 - amino - 3 - (4-hydroxy-3,5-diiodophenyl) - propanowego) chloro (1,10 - fenantrolina) copper (ii) of the formula with 1.