Peptidomimetics and their application in the therapy of intestine cancer and in ensuring their proper peristalsis

摘要

the subject application is peptydomimetyki.one of the compounds on the notification is presented to link general formula where: r1 is side chain d - amino acid chosen among: d - al, d - tre, d - d - ser, met, leu (d -, d - glu,d - asp, d - or d - lys arg, r2 means nothing or the rest of the l - aminokwasowu0105 chosen from gly or lys or the rest of dipeptydowu0105 l - gly - l - lys, r3 means the rest of the l - aminokwasowu0105 chosen from: phe or trp.r4 means nothing or the rest of the l - aminokwasowu0105 lys, r5 means a linear saturated or unsaturated hydrocarbon chain of general formula cnhm, where n is an integer from 1 to 4.however, m is an even integer from 2 to 10.r6 - 10 means independently chosen from hydrogen substituent: hydroksylowego, methyl, formylowego, carboxylic, metoksykarbonylowego, karbamoilowego, cyjanowego, amine -,metyloaminowego, dimetyloaminowego, jodkowego, fluorkowego, nitrowego or acid.the declaration also includes applying the peptydomimetyku00f3w in therapy of intestinal and ensuring their proper perystaltyki.described in the cytostatyczny and cytotoxic compounds have effect in relation to intestinal cancer cells.have affinity to receptors and the environment? and act as opioid antagonists. they are intended for administration by the gastrointestinal system, in the form of tablets, infusions, injections or implants.