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BIOCOMPATIBLE DEGRADABLE POLYMERIC BIOCOMPOSITES WITH POTENTIAL MEDICAL APPLICATION AND PROCESS FOR PREPARING THE SAME

机译:具有潜在医学应用的生物相容性可降解聚合物生物复合材料及其制备方法

摘要

The invention relates to a biocompatible and degradable polymeric composite with medical application and to a process for preparing the same. According to the invention, the composite comprises 97...98% polyhydroxybutirate-co-valerate, 1% vitamin E and 1...2% bacterial cellulose, the percentage being expressed by mass. The process, as claimed by the invention, consists in processing the raw material in melt, at a temperature of 180°C, mixing them for 6 min, at a rotation speed of 40 rpm, followed by the hot pressing of the mixture at 185°C at a pressure of 147 bar, to result in stable films of 200x200x0.1 mm, having a cellular viability of 86.67...94% in 24 h, exhibiting cytocompatibility, biocompatibility and time-controlled degradability.
机译:本发明涉及具有医学应用的生物相容性和可降解的聚合物复合材料及其制备方法。根据本发明,该复合材料包含97 ... 98%的聚羟基丁酸-共-戊酸酯,1%的维生素E和1 ... 2%的细菌纤维素,该百分比以质量表示。如本发明所要求的,该方法在于在180℃的温度下在熔融状态下加工原料,以40rpm的转速将它们混合6分钟,然后在185℃下热压混合物。在147 bar的压力下于°C放置,得到200x200x0.1 mm的稳定膜,在24小时内的细胞活力为86.67 ... 94%,表现出细胞相容性,生物相容性和时间控制的降解性。

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