FABRICATION OF POROUS CERAMIC-POLYMER BIOCOMPOSITES FOR MEDICAL APPLICATION BY MELT INFILTRATION PROCESS

摘要

A method for manufacturing a ceramic-polymer bio-composite as a porous scaffold material by using a melt infiltration process is provided to prepare a porous sintered body by using a spherical PMMA as a pore former, and to improve an organic suitableness and a mechanic characteristic by achieving an optimal pore size and porosity proper for growing and settling an osteoblast and osteoclast when cultivating a living cell. A method for manufacturing a ceramic-polymer bio-composite as a porous scaffold material by using a melt infiltration process includes the steps of: preparing a ceramic powder by ball-milling a mixture which is resulted from that a porous scaffold material is mixed with a polyethylene glycol as a forming auxiliary agent and an alcohol in a closed container, in a wet state for 22 to 24 hours by using an alumina ball, and then by drying the mixture for 2 to 4 hours in an oven with a temperature of 85 to 95 Deg.C; manufacturing a porous ceramic by ball-milling a mixture which is resulted from that the ceramic powder is mixed with a spherical polymethyl methacylate in a closed container, in a dry state also for 22 to 24 hours by using the alumina ball,; forming the porous ceramic into a disk type cylindrical shape by using a single-axis compressor; degreasing the formed, porous ceramic at 605 to 750 Deg.C for 1 to 3 hours and then sintering it at 1100 to 1300 deg.C for 1 to 3 hours; and dipping the degreased and sintered, porous ceramic into a melt biopolymer at 110 to 120 deg.C, and then maintaining the temperature for 5 to 10 minutes.