HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF

摘要

COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION IN A VERTEBRATE SUBJECT ARE PROVIDED. IN PARTICULAR, HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO DENGUE VIRUS ISOLATED FROM EBV IMMORTALIZED B CELLS DERIVED FROM PATIENTS WHO HAVE RECOVERED FROM DENGUE INFECTION ARE DISCLOSED. METHODS ARE PROVIDED FOR ADMINISTERING SUCH ANTIBODIES TO A VERTEBRATE SUBJECT IN AN AMOUNT EFFECTIVE TO REDUCE, ELIMINATE, OR PREVENT RELAPSE FROM INFECTION. FIGURE 1