PROCESS FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS WITH MONOPHOSPHINE LIGANDS

摘要

The invention relates to a process comprising the following process steps: a) introducing an ethylenically unsaturated compound; b) adding a monophosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a monophosphine ligand; c) adding an aliphatic alcohol; d) supplying CO; e) heating the reaction mixture, the ethylenically unsaturated compound being reacted to form an ester; where the monophosphine ligand is a compound of formula (I) where R1 is selected from -(C1-C12)-alkyl, -O-(C1-C12)-alkyl, -O-(C6-C20)-aryl, -(C6-C20)-aryl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -(C3-C20)-heteroaryl; R2 is selected from -(C6-C20)-aryl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -(C3-C20)-heteroaryl; R3 is -(C3-C20)-heteroaryl; and R1, R2 and R3 may each independently be substituted by one or more substituents selected from -(C1-C12)-alkyl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -O-(C1-C12)-alkyl, -O-(C1-C12)-alkyl-(C6-C20)-aryl, -O-(C3-C12)-cycloalkyl, -S-(C1-C12)-alkyl, -S-(C3-C12)-cycloalkyl, -COO-(C1-C12)-alkyl, -COO-(C3-C12)-cycloalkyl, -CONH-(C1-C12)-alkyl, -CONH-(C3-C12)-cycloalkyl, -CO-(C1-C12)-alkyl, -CO-(C3-C12)-cycloalkyl,-N-[(C1-C12)-alkyl]2,-(C6-C20)-aryl, -(C6-C20)-aryl-(C1-C12)-alkyl, -(C6-C20)-aryl-O-(C1-C12)-alkyl, -(C3-C20)-heteroaryl, -(C3-C20)-heteroaryl-(C1-C12)-alkyl, -(C3-C20)-heteroaryl-O-(C1-C12)-alkyl, -COOH, -OH, -SO3H, -NH2, halogen.