PROCESS FOR THE ALKOXYCARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS WITH MONOPHOSPHINE LIGANDS

摘要

The present invention a) method of introducing an ethylenically unsaturated compound; b) adding a compound comprising a monophosphine ligand and Pd, or Adding a complex comprising a Pd and a monophosphine ligand; c) method of adding aliphatic alcohol; d) method of supplying CO; e) heating the reaction mixture, wherein the ethylenically unsaturated compounds react to form esters Wherein the monophosphine ligand is a compound of Formula (I). Formula I Where R ¹ is — (C ₁ -C ₁₂ ) -alkyl, -O- (C ₁ -C ₁₂ ) -alkyl, -O- (C ₆ -C ₂₀ ) -aryl,-(C ₆ -C ₂₀ ) -aryl ,-(C ₃ -C ₁₂ ) -cycloalkyl,-(C ₃ -C ₁₂ ) -heterocycloalkyl,-(C ₃ -C ₂₀ ) -heteroaryl; R ² is — (C ₆ -C ₂₀ ) -aryl,-(C ₃ -C ₁₂ ) -cycloalkyl,-(C ₃ -C ₁₂ ) -heterocycloalkyl,-(C ₃ -C ₂₀ ) -heteroaryl Is selected from; R ³ is-(C ₃ -C ₂₀ ) -heteroaryl; R ¹ , R ² and R ³ are each independently-(C ₁ -C ₁₂ ) -alkyl,-(C ₃ -C ₁₂ ) -cycloalkyl,-(C ₃ -C ₁₂ ) -heterocycloalkyl, -O - (C ₁ -C ₁₂₎ - _{alkyl, -O- (C 1 -C 12)} - alkyl, - (C ₆ -C ₂₀₎ - _{aryl, -O- (C 3 -C 12)} - cycloalkyl, -S - (C ₁ -C ₁₂₎ - _{alkyl, -S- (C 3 -C 12)} - _{cycloalkyl, -COO- (C 1 -C 12)} - _{alkyl, -COO- (C 3 -C 12)} - cyclohexane _{alkyl, -CONH- (C 1 -C 12)} - _{alkyl, -CONH- (C 3 -C 12)} - _{cycloalkyl, -CO- (C 1 -C 12)} - alkyl, -CO- (C ₃ -C _{12)cycloalkyl, -N - [(C 1 -C} 12) - _{alkyl] 2, - (C 6 -C} 20) - aryl, - (C ₆ -C ₂₀₎ aryl - (C ₁ -C ₁₂ ) -Alkyl,-(C ₆ -C ₂₀ ) -aryl-O- (C ₁ -C ₁₂ ) -alkyl,-(C ₃ -C ₂₀ ) -heteroaryl,-(C ₃ -C ₂₀ ) -heteroaryl - (C ₁ -C ₁₂₎ - _{alkyl, - (C 3 -C 20)} - heteroaryl, -O- (C ₁ -C ₁₂₎ - _{alkyl, -COOH, -OH, -SO 3 H} , -NH 2, It may be substituted by one or more substituents selected from halogen.