5-arylpyrid 2,3-e 1,4 thiazepinone derivatives with mitochondrial sodium / calcium exchanger blocking activity

摘要

5-arylpyrid [2,3-e] [1,4] thiazepinone derivatives with mitochondrial sodium / calcium exchanger blocking activity. # {IMAGE-01} # The present invention relates to compounds of general formula (I), and its use in the manufacture of useful medicines for the treatment of neurodegenerative diseases, stroke, epilepsy, diabetes or, in general, any disease or pathology caused by altered biological functions where the mitochondrial sodium / calcium exchanger is involved. These diseases have been described as having mitochondrial dysfunction and an alteration of homeostasis of Ca {sup, 2 +} in neurons. Therefore, the compounds of the general formula (I) have the Na {sup, +} / Ca {sup, 2 +} exchanger of the mitochondria as biological targets. In addition, given the lack of potent and selective pharmacological tools to study the Na {sup, +} / Ca {sup, 2 +} exchanger of mitochondria, the compounds of the invention are useful for studying the physiology and pathophysiology of this target. biological in processes where its role has been discovered, or in future experimental observations. The present invention can be framed in the field of the pharmaceutical industry.