Composition to promote cardiac recovery after myocardial infarction (MI)

摘要

Composition to promote cardiac recovery after myocardial infarction (im). # The present invention offers a solution to the lack of compounds capable of efficiently preventing cardiac muscle deterioration after MI, and improving the long-term prognosis. of patients who have suffered an MI. The present invention claims compounds capable of inhibiting the expression of transcription factor Yy1 in cardiac cells, thus reducing the expression of the ST2s gene and allowing the activation of the IL33 / ST2L cardioprotective signaling chain. The present invention also describes a screening method that allows identifying compounds capable of improving the long-term prognosis of patients who have suffered an MI. This method is based on identifying the compounds capable of inhibiting Yy1 expression and / or activating the IL33 / ST2L cardioprotective signaling chain in cardiac cells.