Use of 4H-pyrano 2,3-c pyrazole derivatives in the treatment of neurodegenerative diseases

摘要

The present invention relates to the use of 3-alkyl-6-amino-4-aryl-1,4-dihydropyran [2,3-c] pyrazol-5-carbonitrile derivatives with glycogen synthase kinase kinase inhibitory activity 3 {be}, inducing effect of transcription factor Nrf2, and neuroprotective capacity. Another aspect of the invention relates to the use of the derivatives object of this invention for the treatment of diseases whose pathogenesis involves the abnormal activity of this enzyme and / or oxidative stress and / or diseases that occur with deregulation of gene activity. of phase II activated by the Nrf2 factor, such as diseases that occur with an inflammatory component or neurodegenerative diseases.