Use of 4H-pyrano 2,3-c pyrazole derivatives in the treatment of neurodegenerative diseases

摘要

The present Invention relates to the use of alkyl derivatives of 3 - 6 - amino - 4 - aryl - 1.4 - dihidropirano [2,3-c] - 5 - carbonitrilo with pyrazole kinase Inhibitory activity of glycogen synthase kinase 3 {be},Inducing effect of Transcription Factor Nrf2 and neuroprotective ability.Another aspect of the invention relates to the use of the derived object of this Invention to the treatment of diseases involved in the Pathogenesis of the abnormal activity of this Enzyme and / or theOxidative Stress and / or diseases that course with deregulation of the activity of Phase II genes Activated by the factor Nrf2,As a component of the diseases associated with inflammatory and Neurodegenerative Diseases.