Improve the potential for return and repair of stem cells in vascular lesions

摘要

A composition comprising treated CD34 + endothelial progenitor cells (EPCs), said treated CD34 + EPC cells being obtained by procuring CD34 + EPCs from a subject and treating said procured CD34 + EPC cells, ex vivo, with a blocking activity of the TGF-β1 agent in said subjects. cells to obtain treated CD34 + EPCs, for use in a method of treating vascular lesions, wherein said TGF-β1 agent blocking activity in said cells is a specific antisense nucleotide for a mRNA sequence encoding TGF-β1 or is an antibody specific for TGF-β1.