JAK3 imidazopyridazine inhibitors and their use for the treatment of inflammatory and autoimmune diseases

摘要

A compound having the formula II: ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof, in which: R1a is independently each time H, F, Cl, Br, - (CH2) rORb appears, alkyl C1-6 substituted with 0-5 Ra or - (CH2) 3-6 membered r-carbocyclic substituted with 0-2 Ra; R1b is hydrogen, - (CH2) rC (O) R1d, - (CH2) rC (O) ORb, - (CH2) rS (O) 2Re, C1-6 alkyl substituted with 0-2 Ra, a - (CH2) r-5-7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-2 Ra; or a 5-7 membered - (CH2) r-heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O and S substituted with 0-2 Ra; R1d is independently each time hydrogen appears, C1-6 alkyl substituted with 0-2 Rd, haloalkyl C1- 6, C (O) NRcRc, C3-6 cycloalkyl substituted with 0-2 Rd or (CH2) r-phenyl substituted with 0-2 Ra, a 4-10 membered heterocycle containing 1-4 heteroatoms selected from N, O and S, substituted with 0-3 Ra; R2 is selected from: