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Compounds, compositions and corresponding uses, for the prevention and / or treatment of dyslipidemias

机译:用于预防和/或治疗血脂异常的化合物,组合物和相应用途

摘要

Compound comprising a polar head, comprising at least one hydroxyl residue, on which a single unsaturated fatty acid comprising between 16 and 24 carbon atoms and having 1 to 6 unsaturations in cis configuration is used for use in preventing and / or treating, in a subject, a hypoxia lipointoxication associated with the excess presence in the biological membranes of non-adipocyte cells, fatty acids, in particular saturated long chain fatty acids and / or sterols; said compound being chosen from manide monooleate, 3-hydroxy-2,2-bis (hydroxymethyl) propyl oleate, N, Ndiethanoleamide and mixtures thereof; said lipointoxication being associated by hypoxia in said subject to a pulmonary pathology.
机译:包含极性头的化合物,其包含至少一个羟基残基,在其上用于预防和/或治疗对象的是单个不饱和脂肪酸,该不饱和脂肪酸包含16至24个碳原子并且具有1至6个顺式构型的不饱和键。 ,低氧脂肪中毒,与非脂肪细胞,脂肪酸,特别是饱和长链脂肪酸和/或固醇的生物膜中过量存在有关;所述化合物选自:亚油酸单油酸酯,3-羟基-2,2-双(羟甲基)丙基油酸酯,N,N-二乙醇酰胺及其混合物;所述脂中毒与所述受试者的肺部缺氧有关。

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