New antibiotic preparation method and platform system based on it

摘要

An antibiotic preparation method, comprising the following steps: (1) determining selected targets of prokaryotic cells, eukaryotic cells, and viruses with phospholipid bilayer membranes as the basic structure of their cell membrane or envelope; (2) design a molecular structure of said new antibiotic according to the following general formula: ** Formula ** in which R is the recognition region, which specifically recognizes said targets or is combined with said targets and F is the region effector, which produces pharmaceutical effects on said targets, said pharmaceutical effects causing death; (3) establish a library of molecular structure of the recognition region, which comprises artificially preparing artificial substances that specifically recognize said targets as well as obtaining a molecular structure of these artificial substances; (4) establishing a library of molecular structure of the effector region, wherein said effector region comprises a bioactive substance that can form an ion channel or a pore in said phospholipid bilayer membranes; (5) design a recombinant molecular structure library based on said molecular structure libraries of the recognition and effector regions according to said general formula by means of structural adjustment, structural recombination and / or structural confirmation of the molecular structures of the effector region or recognition; (6) based on said library of recombinant molecular structure, preparing and verifying recombinants to obtain candidates for new antibiotics; and (7) explore candidates' compliance with the requirements as medicine to obtain new antibiotics; wherein said artificial substances are antibody mimetics designed according to the amino acid sequence of an immunoglobulin that can specifically recognize a unique substance in said targets.