Vaccine antigen capable of inducing cross-reactive and neutralizing antibodies against high-risk type human papillomavirus

摘要

A capsid that is an aggregate formed by the chimeric protein assembly composed of the genotype 16 human papilloma virus (HPV) L1 protein and an HPV16 L2 epitope inserted into the loop region of the HPV16 L1 protein, in which the region for L2 epitope insertion is an amino acid region 430 to 433 and epitope L2 consists of an amino acid sequence represented by: GGLGIGTGSGTGGRTGYIPL (hereinafter referred to as L2 epitope 56-75).